abstract：:The expression of pro-gastrin-releasing peptide (proGRP) in medullary thyroid carcinoma (MTC) and other histological types of thyroid carcinoma was studied by an immunohistochemical technique, using polyclonal anti-proGRP antiserum. Immunoreactivity for proGRP was detected exclusively in MTC (n = 7); other histologica...

journal_title：Oncology

authors： Inaji H,Komoike Y,Motomura K,Higashiyama M,Ohtsuru M,Funai H,Kasugai T,Koyama H

更新日期：2000-08-01 00:00:00

abstract：:The expression of cyclin-dependent kinase 1 (cdc2), cyclin A and cyclin B1 was immunohistochemically studied in 101 hepatocellular carcinomas (HCC). cdc2 overexpression was directly related to advanced stage, portal invasion, intrahepatic metastasis, poor differentiation, high alpha-fetoprotein level, large size, high...

journal_title：Oncology

authors： Ito Y,Takeda T,Sakon M,Monden M,Tsujimoto M,Matsuura N

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:This study was performed to investigate the activity and safety of high dose 5-fluorouracil (5-FU) given as a weekly 24-hour infusion in combination with folinic acid plus mitomycin C in patients with advanced gastric cancer. PATIENTS AND METHODS:Chemonaive patients with locally advanced inoperable, recurrent ...

journal_title：Oncology

authors： Kretzschmar A,Reichardt P,Thuss-Patience PC,Hohenberger P,Benter T,Dörken B,Köhne CH

更新日期：2000-06-01 00:00:00

abstract：:Novel human estrogen receptor (ER)-beta was identified in cDNA libraries from human testis. ER-beta specifically expresses in testis, ovary, thymus, spleen, osteoblasts and fetus. ER-beta might not conserve the same physiological functions as does ER-alpha. Therefore, the clinical significance of the expression of ER-...

journal_title：Oncology

authors： Fujimoto J,Hirose R,Sakaguchi H,Tamaya T

更新日期：2000-05-01 00:00:00

abstract：:We investigated facilitation of invasion by growth factors and chemotactic factors in tumor cell lines, particularly hepatocellular carcinoma. Hepatoma cells (PLC/PRF/5 and Hep G2) showed strong chemotaxis toward their respective conditioned media while metastatic pancreatic cancer cells (SU.86.86) and colon cancer ce...

journal_title：Oncology

authors： Ito H,Miyazaki M,Nishimura F,Nakajima N

更新日期：2000-04-01 00:00:00

abstract：:Lymphomas, which are frequently subdivided into Hodgkin's disease and non-Hodgkin's lymphoma, represent one of the more curable cancers that present as a solid tumor. Unfortunately, most patients cannot be cured with conventional chemotherapy, therefore new techniques have been developed including high-dose chemothera...

journal_title：Oncology

authors： Armitage JO

更新日期：2000-04-01 00:00:00

abstract：:Lymph node and distant metastasis were comparatively studied in 225 oral carcinomas, and factors predisposing toward metastasis were investigated using clinical and immunohistopathological approaches. Neither the sites of tumors nor T-stage was correlated with either type of metastasis. Tumor cell differentiation was ...

journal_title：Oncology

authors： Osaki T,Kimura T,Tatemoto Y,Yamamoto T,Yoneda K

更新日期：2000-02-01 00:00:00

abstract：:Tumor cell apoptosis, proliferation and p27 expression using an in situ apoptosis detection kit, anti-Ki67 antibody and anti-p27 antibody were investigated in 171 colorectal adenocarcinoma specimens, together with the assessment of mutated p53 expression. No apparent association was observed among p27 expression, muta...

journal_title：Oncology

authors： Tenjo T,Toyoda M,Okuda J,Watanabe I,Yamamoto T,Tanaka K,Ohtani M,Nohara T,Kawasaki H,Tanigawa N

更新日期：2000-01-01 00:00:00

abstract：:Intratumoral metabolism and synthesis of estrogens are considered to play very important roles in the pathogenesis and development of various sex steroid-dependent neoplasms including breast and endometrial carcinoma. 17 beta-Hydroxysteroid dehydrogenase (17 beta-HSD) isozymes catalyze the interconversion of estradiol...

journal_title：Oncology

authors： Sasano H,Suzuki T,Takeyama J,Utsunomiya H,Ito K,Ariga N,Moriya T

更新日期：2000-01-01 00:00:00

abstract：:Autoantibodies (AAb) directed against the nuclear phosphoprotein p53 can be detected in patients with various forms of cancer. The objective was to determine the prevalence of p53 AAb at the time of diagnosis in ovarian cancer patients and to correlate the presence of p53 AAb with clinicopathological parameters. Sera ...

journal_title：Oncology

authors： Vogl FD,Stickeler E,Weyermann M,Köhler T,Grill HJ,Negri G,Kreienberg R,Runnebaum IB

更新日期：1999-11-01 00:00:00

abstract：:While central ports are located at the chest, peripheral ports (PP) are inserted at the patients' forearms. Two new PPs (Healthport miniMax((R)) and Bard Titan Low Profile Port) and two well-established types (Port-A-Cath((R)) P.A.S. Port and PeriPort(TM) peripheral access system) were tested. 125 patients were given ...

journal_title：Oncology

authors： Lersch C,Eckel F,Sader R,Paschalidis M,Zeilhofer F,Schulte-Frohlinde E,Theiss W

更新日期：1999-11-01 00:00:00

abstract：:To clarify the inhibitory effect of telomere-mimic oligonucleotides on human cancer cell lines, we synthesized 18-mers (18T; n = 3), 24-mers (24T; n = 4) and 30-mers (30T; n = 5) of telomere-mimic phosphorothioate oligodeoxy nucleotides [5'-d(TTA GGG)n-3'] and examined their effects on the proliferation of human tumor...

journal_title：Oncology

authors： Saeki T,Takashima S,Tachibana M,Koga M,Hiyama E,Salomon DS,Holland JF,Ohnuma T

更新日期：1999-10-01 00:00:00

abstract：:This multicenter phase II study evaluated the efficacy of the FEM regimen (5-fluorouracil 333 mg/m(2) each week, epirubicin 30 mg/m(2) once every 4 weeks and mitomycin-C 2.7 mg/m(2) once every 2 weeks) administered by hepatic artery infusion (HAI) for unresectable hepatic metastases of gastric cancer. The response rat...

journal_title：Oncology

authors： Kumada T,Arai Y,Itoh K,Takayasu Y,Nakamura K,Ariyoshi Y,Tajima K

更新日期：1999-10-01 00:00:00

abstract：:Liver is involved in about 5-8% of newly diagnosed Hodgkin's disease (HD) cases. The incidence reaches up to 50-60% in postmortem studies. In the literature only a few cases of idiopathic cholestatic jaundice have been described without an apparent cause and a paraneoplastic etiology has been suggested. We report 2 ca...

journal_title：Oncology

authors： Yalçin S,Kars A,Sökmensüer C,Atahan L

更新日期：1999-07-01 00:00:00

abstract：:To improve our understanding of the basic biological mechanisms of Hürthle cell tumours (HCT), proliferative activity in 20 HCT was determined by Ag-NOR (nucleolar organiser regions) counting and by immunohistochemical markers proliferating cell nuclear antigen (PCNA) and MIB-1. Ten surgically removed Hürthle cell ade...

journal_title：Oncology

authors： Cör A

更新日期：1999-07-01 00:00:00

abstract：:After nearly four decades of clinical experience with the fluoropyrimidines, 5-fluorouracil (5-FU) remains an integral part of chemotherapy for colorectal cancer. A range of 5-FU treatment regimens with or without biochemical modulation are currently used and toxicity appears to be schedule dependent. The use of oral ...

journal_title：Oncology

authors： Brito RA,Medgyesy D,Zukowski TH,Royce ME,Ravandi-Kashani F,Hoff PM,Pazdur R

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Clinical significance of immunohistochemically detectable level of p53 protein has been reported, but with some limitation as a prognosticator of bladder cancer patients. Whether or not simultaneous evaluation of mdm2 and p53 expression in bladder cancer exceed the prognostic significance of conventional his...

journal_title：Oncology

authors： Shiina H,Igawa M,Shigeno K,Yamasaki Y,Urakami S,Yoneda T,Wada Y,Honda S,Nagasaki M

更新日期：1999-04-01 00:00:00

abstract：INTRODUCTION:Carcinoma of the biliary system is a rare tumor entity, and patients with advanced disease face a dismal prognosis. Because of the absence of standard chemotherapy for advanced biliary carcinoma, we have performed two consecutive studies to evaluate the clinical potential of 5-fluorouracil, leucovorin and ...

journal_title：Oncology

authors： Raderer M,Hejna MH,Valencak JB,Kornek GV,Weinländer GS,Bareck E,Lenauer J,Brodowicz T,Lang F,Scheithauer W

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Even though the pathological background contributes to lymph node metastasis, the biological characteristics of tumors have also gained wide attention. In this study, the expression of the cadherin-catenin complex and p53 was studied in early gastric cancer. Their correlation with lymph node m...

journal_title：Oncology

authors： Xiangming C,Hokita S,Natsugoe S,Tanabe G,Baba M,Takao S,Kuroshima K,Aikou T

更新日期：1999-01-01 00:00:00

abstract：:Cyclin D3 promotes cell cycle progression but its expression and prognostic significance in human colorectal cancer is unknown. This study assayed cyclin D3 expression against cell cycle phase fraction and Duke's stage in 35 fresh human primary colorectal cancers. DNA content, cell cycle phase fraction and cyclin D3 e...

journal_title：Oncology

authors： Watson DS,Brotherick I,Shenton BK,Wilson RG,Angus B,Varma JS,Campbell FC

更新日期：1999-01-01 00:00:00

abstract：:A loss of heterozygosity (LOH) at the DCC gene locus was detected in colorectal tumors, and this LOH might be related to metastasis. The aim of this study was to determine DCC protein expression in colorectal cancer and to evaluate its prognostic value. Allelic loss of the DCC locus was observed in 16 of the 23 patien...

journal_title：Oncology

authors： Saito M,Yamaguchi A,Goi T,Tsuchiyama T,Nakagawara G,Urano T,Shiku H,Furukawa K

更新日期：1999-01-01 00:00:00

abstract：:The serum detection of S100B, a new melanoma marker, has shown clinical significance in early studies. The aim of our study of 1, 339 serum samples from 412 different melanoma patients and 107 control patients was to prove the prognostic value of serum S100B levels in melanoma patients at different stages of disease a...

journal_title：Oncology

authors： Hauschild A,Engel G,Brenner W,Gläser R,Mönig H,Henze E,Christophers E

更新日期：1999-01-01 00:00:00

abstract：:The best treatment for primary gastric lymphomas (PGL) has not yet been defined. Eighty-three patients with stage I/II PGL are documented, focusing on prognostic factors, treatment-related morbidity and mortality, and therapeutic outcome. Chemotherapy improved survival in comparison to local treatments, i.e. gastrecto...

journal_title：Oncology

authors： Ferreri AJ,Cordio S,Paro S,Ponzoni M,Freschi M,Veglia F,Villa E

更新日期：1999-01-01 00:00:00

abstract：:The role of estrogen and estrogen-related growth factors in the mechanism of hormone dependency of endometrial adenocarcinoma cells was investigated. The proliferation of hormone-responsive human endometrial adenocarcinoma cells (Ishikawa cells), which possess both estrogen and progesterone receptors, was optimally st...

journal_title：Oncology

authors： Hata H,Hamano M,Watanabe J,Kuramoto H

更新日期：1998-12-01 00:00:00

abstract：:Malignant fibrous histiocytoma (MFH), the most common soft-tissue sarcoma, consists mainly of two different cell populations: histiocytelike and fibroblastlike cells. It has been suggested to contain a large amount of reactive histiocytes and fibroblasts hard to distinguish from the tumor cells. In this study, the clo...

journal_title：Oncology

authors： Fujita MQ,Hashida N,Shin M,Nakanishi H,Yoshihara W,Aozasa K

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:The therapeutic potential of chemotherapy in the treatment of recurrent or metastatic non-small cell lung carcinoma (NSCLC) seems modest. Thus, the search for novel agents and combination regimens with a superior therapeutic index has a high priority. The present combination regimen consisting of mitomycin C...

journal_title：Oncology

authors： Hejna M,Kornek GV,Raderer M,Marosi L,Schneeweiss B,Greul R,Weinländer G,Valencak J,Huber H,Scheithauer W

更新日期：1998-11-01 00:00:00

abstract：:The encouraging results that have been reported for cisplatin combination chemotherapy in a minority of patients with cancer of unknown primary (CUP) together with the previously shown equal activity of carboplatin in this setting, prompted us to investigate the effectiveness of a carboplatin-containing regimen in a p...

journal_title：Oncology

authors： Briasoulis E,Tsavaris N,Fountzilas G,Athanasiadis A,Kosmidis P,Bafaloukos D,Skarlos D,Samantas E,Pavlidis N

更新日期：1998-09-01 00:00:00

abstract：:In the present study, an analysis of whether expression of nm23-H1 and nm23-H2 proteins has prognostic significance was performed. A series of 95 renal cell carcinomas was analyzed for nuclear grade, tumor size (larger than 50 mm or not), staging in the Robson system and expression of nm23-H1 and nm23-H2, as well as p...

journal_title：Oncology

authors： Nakagawa Y,Tsumatani K,Kurumatani N,Cho M,Kitahori Y,Konishi N,Ozono S,Okajima E,Hirao Y,Hiasa Y

更新日期：1998-07-01 00:00:00

abstract：:This study sought to examine the relationship between MUC1 expression at the deepest invasive portion, invasive/metastatic potential, and prognosis of colorectal cancer in relation to cellular proliferation. MUC1 expression was detected immunohistochemically using KL-6 antibody (anti-MUC1 monoclonal antibody) in 100 s...

journal_title：Oncology

authors： Hiraga Y,Tanaka S,Haruma K,Yoshihara M,Sumii K,Kajiyama G,Shimamoto F,Kohno N

更新日期：1998-07-01 00:00:00

abstract：:The association of MMP-2 (matrix metalloproteinase 2, 72-kD collagenase IV) with invasive and metastatic capacity of tumor cells has implicated a potential role in the prognosis for cancer patients. However, no larger study has been done to prove this hypothesis. The present study was therefore designed to investigate...

journal_title：Oncology

authors： Allgayer H,Babic R,Beyer BC,Grützner KU,Tarabichi A,Schildberg FW,Heiss MM

更新日期：1998-03-01 00:00:00

abstract：:This study evaluated the influence of bile acid load on the DNA distribution pattern of proliferated bile ductules and cholangiocarcinoma induced by diisopropanolnitrosamine. Ninety hamsters were separated into control, tauro- and deoxycholic acid (DCA) groups. The DNA distribution pattern of intrahepatic lesions at 1...

journal_title：Oncology

authors： Kinami Y,Miyakoshi M,Fujikawa K

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:In order to determine whether infection with Helicobacter pylori might be associated with pancreatic adenocarcinoma, we performed a study to compare the H. pylori seroprevalence rate between patients with pancreatic carcinoma and matched control subjects. PATIENTS AND METHODS:Blood samples from 92 patients wit...

journal_title：Oncology

authors： Raderer M,Wrba F,Kornek G,Maca T,Koller DY,Weinlaender G,Hejna M,Scheithauer W

更新日期：1998-01-01 00:00:00

abstract：:Rapid advances in our understanding of the biology and pathology of lymphoproliferative disorders, permitted mainly by new diagnostic tools, constantly change our approach to this heterogenous group of disorders. In this review of the more indolent subgroup of lymphoproliferative disorders, some of the recent advances...

journal_title：Oncology

authors： Eek R,Falkson G

更新日期：1997-11-01 00:00:00

abstract：UNLABELLED:The outlook for patients with testicular germ cell cancer was dramatically improved by the introduction of cisplatin. Well-known side effects of cisplatin (nausea, vomiting, nephrotoxicity, myelosuppression) can be managed with preventive methods. The long life expectancy after this therapy draws attention t...

journal_title：Oncology

authors： Biró K,Baki M,Büki B,Noszek L,Jókúti L

更新日期：1997-09-01 00:00:00

abstract：:To determine the relationship between neoplastic transformation and increased genetic instability, spontaneous and induced mutation rates were compared in a nontumorigenic, immortalized human bronchial epithelial cell line (NL20) and a tumorigenic cell line (NL20T) spontaneously derived from the NL20 line. Using the h...

journal_title：Oncology

authors： Wittenkeller JL,Storer B,Bittner G,Schiller JH

更新日期：1997-07-01 00:00:00

abstract：:Systemic chemotherapy for advanced gastric cancer is frequently associated with significant treatment-related toxicity, which is particularly serve in patients presenting with a poor general condition. A search for effective and low-toxic regimens for this group of patients is mandatory. A weekly 24-hour infusion of h...

journal_title：Oncology

authors： Hsu CH,Yeh KH,Chen LT,Liu JM,Jan CM,Lin JT,Chen YC,Cheng AL

更新日期：1997-07-01 00:00:00

abstract：:This is a phase II study to evaluate the efficacy and toxicity of short-course carboplatin in advanced-stage nasopharyngeal carcinoma (NPC). Thirty-three previously untreated stage III-IV NPC patients were studied. Carboplatin was given as a rapid intravenous injection every 3 weeks. The dose of carboplatin was calcul...

journal_title：Oncology

authors： Chi KH,Chang YC,Chan WK,Liu JM,Law CK,Lo SS,Shu CH,Yen SH,Whang-Peng J,Chen KY

更新日期：1997-05-01 00:00:00

abstract：:The relationship between p53 overexpression and clinicopathologic variables in gastric cancer was evaluated using 304 paraffin-embedded gastric tumor tissues. DO7, a murine monoclonal antiserum to p53 protein, was used for the immunohistochemical analysis. Positive staining was found in 129 tumors (42.2% of all tumors...

journal_title：Oncology

authors： Kim JH,Uhm HD,Gong SJ,Shin DH,Choi JH,Lee HR,Noh SH,Kim BS,Cho JY,Rha SY,Yoo NC,Chung HC,Roh JK,Min JS,Lee KS,Kim BS

更新日期：1997-03-01 00:00:00

abstract：GOALS OF WORK:There is a need for an effective and nontoxic chemotherapy for palliative indication in non-Hodgkin's lymphoma (NHL) patients who relapse after conventional or high-dose chemotherapy. The aim of this study was to investigate the feasibility and efficacy of peroral chemotherapy in the palliative treatment ...

journal_title：Oncology

authors： Salminen E,Nikkanen V,Lindholm L

更新日期：1997-03-01 00:00:00

abstract：:The activity and toxicity of UFT (Tegafur and Uracil) in a 4:1 molar concentration, plus leucovorin (LV), were evaluated in the treatment of 45 patients with advanced, bidimensionally measurable metastatic colorectal carcinoma. Initially 350 and later 300 mg/m2/day, plus 150 mg LV, as administered in divided doses eve...

journal_title：Oncology

authors： Pazdur R

更新日期：1997-01-01 00:00:00